TriplexPredict: Triplex DNA Design and Stability Prediction Tool
Sequence Generation Parameters
● Structure (5'→3'): Purine stem + Duplex loop (TTTA) + Pyrimidine stem + TFO loop + Pyrimidine stem.
● Click on any generated sequence entry, expand and view its Thermodynamic Stability Landscape and pH Stability Landscape.
● Sequences containing three consecutive C-G•C⁺ triads are automatically filtered out, as consecutive cytosines may exhibit poor protonation efficiency and introduce potential prediction bias.
● The generated sequences have the potential to form intramolecular triplex DNA, but other possible secondary structures cannot be excluded. Please interpret with caution.
● Click on any generated sequence entry, expand and view its Thermodynamic Stability Landscape and pH Stability Landscape.
● Sequences containing three consecutive C-G•C⁺ triads are automatically filtered out, as consecutive cytosines may exhibit poor protonation efficiency and introduce potential prediction bias.
● The generated sequences have the potential to form intramolecular triplex DNA, but other possible secondary structures cannot be excluded. Please interpret with caution.
Predicting Thermal stability (T₁/₂)
Predicting pH sensibility (pH₁/₂)
Generated Results (Total: 0)
Purine Stem
Duplex Loop (TTTA)
Pyrimidine Stem
TFO Loop
Pyrimidine Stem